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The Proteomics and Metabolomics Program


  • Ezzat, A. A., Tammam, S. N., Hanafi, R. S., Rashad, O., Osama, A., Abdelnaby, E., Magdeldin, S., & Mansour, S. “Different Serum, Different Protein Corona! The Impact of the Serum Source on Cellular Targeting of Folic Acid-Modified Chitosan-Based Nanoparticles”. Molecular pharmaceutics (2022).
    PMID: 35380849

  • Hussein, M.A., Hussein, H.A., Thabet, A.A., Selim, K.M., Dawood, M.A., El-Adly, A.M., Wardany, A.A., Sobhy, A., Magdeldin, S., Osama, A., Anwar, A., “Human Wharton’s Jelly Mesenchymal Stem Cells Secretome Inhibits Human SARS-CoV-2 and Avian Infectious Bronchitis Coronaviruses”. Cells (2022).
    PMID: 35563714

  • Attallah, N. G., Mokhtar, F. A., Elekhnawy, E., Heneidy, S. Z., Ahmed, E., Magdeldin, S., ... & El-Kadem, A. H. “Mechanistic Insights on the In Vitro Antibacterial Activity and In Vivo Hepatoprotective Effects of Salvinia auriculata Aubl against Methotrexate-Induced Liver Injury”. Pharmaceuticals (2022).
    PMID: 35631375

  • Zerfaoui, M., Tsumagari, K., Toraih, E., Errami, Y., Ruiz, E., Elaasar, M.S.M., Krzysztof, M., Sholl, A.B., Magdeldin, S., Soudy, M. and Abd Elmageed, Z.Y. “Nuclear interaction of Arp2/3 complex and BRAFV600E promotes aggressive behavior and vemurafenib resistance of thyroid cancer”. American journal of cancer research (2022).
    PMID: 35968344

  • Magdeldin, S., “The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019”. Lancet. (2022).
    PMID: 35988567

  • Shikshaky, H., Ahmed, E. A., Anwar, A. M., Osama, A., Ezzeldin, S., Nasr, A., Mahgoub, S., & Magdeldin, S. “A Novel Approach of SWATH-Based Metabolomics Analysis Using the Human Metabolome Database Spectral Library. International journal of molecular sciences (2022).
    PMID: 36142821

  • Binsuwaidan, R., Elekhnawy, E., Elseady, W. S., Keshk, W. A., Shoeib, N. A., Attallah, N. G. M., Mokhtar, F. A., Abd El Hadi, S. R., Ahmed, E., Magdeldin, S., & Negm, W. A. “Antibacterial activity and wound healing potential of Cycas thouarsii R.Br n-butanol fraction in diabetic rats supported with phytochemical profiling”. Biomedicine & pharmacotherapy (2022).
    PMID: 36182739

  • Elnaggar, A., Osama, A., Anwar, A. M., Ezzeldin, S., Abou Elhassan, S., Ebeid, H., ... & Magdeldin, S. “Paleoproteomic profiling for identification of animal skin species in ancient Egyptian archaeological leather using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS)”. Heritage Science (2022).

  • Salah, R.A., Nasr, M.A., El-Derby, A.M., Abd Elkodous, M., Mohamed, R.H., El-Ekiaby, N., Osama, A., Elshenawy, S.E., Hamad, M.H.M., Magdeldin, S. and Gabr, M.M. “Hepatocellular carcinoma cell line-microenvironment induced cancer-associated phenotype, genotype and functionality in mesenchymal stem cells”. Life Sciences (2022).
    PMID: 34826437

  • Amer, N., Taha, H., Hesham, D., Al-Shehaby, N., Mosaab, A., Soudy, M., Osama, A., Mahmoud, N., Elayadi, M., Youssef, A. and Elbeltagy, M., et al. “Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors”. Journal of neuro-oncology (2021).
    PMID: 33501605

  • Nafie, Mohamed S., Safaa M. Kishk, Sebaey Mahgoub, and Atef M. Amer. "Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition." Chemical Biology & Drug Design (2021).
    PMID: 34873844

  • Anwar AM, Ahmed EA, Soudy M, Osama A, Ezzeldin S, Tanios A, Mahgoub S, Magdeldin S. Xconnector: Retrieving and visualizing metabolites and pathways information from various database resources. J Proteomics (2021).
    PMID: 34111608

  • Qunaibi E, Basheti I, Soudy M, Sultan I. Hesitancy of Arab Healthcare Workers towards COVID-19 Vaccination: A Large-Scale Multinational Study. Vaccines (Basel) (2021).
    PMID: 34063313

  • Mohammed, Hamdoon A., et al. "Phytochemical Profiling, In Vitro and In Silico Anti-Microbial and Anti-Cancer Activity Evaluations and Staph GyraseB and h-TOP-IIβ Receptor-Docking Studies of Major Constituents of Zygophyllum coccineum L. Aqueous-Ethanolic Extract and Its Subsequent Fractions: An Approach to Validate Traditional Phytomedicinal Knowledge." Molecules (2021). PMID: 33499325

  • Nafie MS, Mahgoub S, Amer AM. Antimicrobial and antiproliferative activities of novel synthesized 6-(quinolin-2-ylthio) pyridine derivatives with molecular docking study as multi-targeted JAK2/STAT3 inhibitors. Chem Biol Drug Des. (2021).
    PMID: 32920942

  • Ashour ME, Allam W, Elsayed W, Atteya R, Elserafy M, Magdeldin S, Hassan MK, El-Khamisy SF. High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice. Cancers (Basel) (2021).
    PMID: 34065967

  • Hegazy, Mostafa M., et al. "Biological and chemical evaluation of some African plants belonging to Kalanchoe species: Antitrypanosomal, cytotoxic, antitopoisomerase I activities and chemical profiling using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometer." Pharmacognosy Magazine (2021).
    DOI: 10.4103/pm.pm_232_20

  • Ezzeldin, Shahd, Aya El-Wazir, Shymaa Enany, Abdelrahman Muhammad, Dina Johar, Aya Osama, Eman Ahmed, Hassan Shikshaky, and Sameh Magdeldin.
    "Current Understanding of Human Metaproteome Association and Modulation." Journal of proteome research (2019).
    PMID: 27535355

  • Soudy M, Anwar AM, Ahmed EA, et al. UniprotR: Retrieving and visualizing protein sequence and functional information from Universal Protein Resource (UniProt knowledgebase). J Proteomics. 2020.
    PMID: 31843688

  • Saadeldin IM, Swelum AA, Elsafadi M, Magdeldin S, et al. Thermotolerance and plasticity of camel somatic cells exposed to acute and chronic heat stress. J Adv Res. 2019.
    PMID: 31969994

  • Burstein R, Henry NJ, Collison ML, Magdeldin S, et al. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017. Nature. 2019.
    PMID: 31619795

  • Morsi M, Kobeissy F, Magdeldin S, et al. A shared comparison of diabetes mellitus and neurodegenerative disorders. J Cell Biochem. 2019.
    PMID: 28681964

  • El-Gammal, Zaynab, et al. "Human-stimulated oocyte extract induces genetic and mitochondrial reprogramming of mesenchymal stromal cells." Plos one 15.5 (2020): e0232759.
    PMID: 32453737

  • Reiner Jr, Robert C., et al. "Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017." The Lancet (2020).
    PMID: 32513411

  • Enany, Shymaa, et al. "Shotgun proteomic analysis of ESBL-producing and non-ESBL-producing Klebsiella Pneumoniae clinical isolates." Microbiological Research 234 (2020): 126423.
    PMID: 32078895

  • Elguoshy, A., Magdeldin, S., Xu, B., Hirao, Y., Zhang, Y., Kinoshita, N., Takisawa, Y., Nameta, M., Yamamoto, K., El-Refy, A., El-Fiky, F., Yamamoto, T., 2016. Why are they missing? : Bioinformatics characterization of missing human proteins. Journal of proteomics 149, 7-14.
    PMID: 27535355

  • Magdeldin, S., Hirao, Y., El Guoshy, A., Xu, B., Zhang, Y., Fujinaka, H., Yamamoto, K., Yates, J.R., 3rd, Yamamoto, T., 2016a. Comprehensive data analysis of human ureter proteome. Data in brief 6, 853-857.
    PMID: 27535355

  • Magdeldin, S., Hirao, Y., Elguoshy, A., Xu, B., Zhang, Y., Fujinaka, H., Yamamoto, K., Yates, J.R., 3rd, Yamamoto, T., 2016b. A proteomic glimpse into human ureter proteome. Proteomics 16, 80-84.
    PMID: 26442468

  • Yaoita, E., Nishimura, H., Nameta, M., Yoshida, Y., Takimoto, H., Fujinaka, H., Kawachi, H., Magdeldin, S., Zhang, Y., Xu, B., Oyama, T., Nakamura, F., Yamamoto, T., 2016. Avian Podocytes, Which Lack Nephrin, Use Adherens Junction Proteins at Intercellular Junctions. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 64, 67-76.
    PMID: 26416242

  • Zhang, Y., Xu, B., Kinoshita, N., Yoshida, Y., Tasaki, M., Fujinaka, H., Magdeldin, S., Yaoita, E., Yamamoto, T., 2015b. Datasets from label-free quantitative proteomic analysis of human glomeruli with sclerotic lesions. Data in brief 4, 180-185.
    PMID: 26217785

  • Magdeldin, S., Elguoshy, A., Yoshida, Y., Hirao, Y., Xu, B., Zhang, Y., Yamamoto, K., Takimoto, H., Fujinaka, H., Kinoshita, N., Yamamoto, T., 2015b. Complementary protein and peptide OFFGEL fractionation for high-throughput proteomic analysis. Analytical chemistry 87, 8481-8488.
    PMID: 26168396

  • Zhang, Y., Muller, M., Xu, B., Yoshida, Y., Horlacher, O., Nikitin, F., Garessus, S., Magdeldin, S., Kinoshita, N., Fujinaka, H., Yaoita, E., Hasegawa, M., Lisacek, F., Yamamoto, T., 2015a. Unrestricted modification search reveals lysine methylation as major modification induced by tissue formalin fixation and paraffin embedding. Proteomics 15, 2568-2579.
    PMID: 25825003

  • Zhang, Y., Xu, B., Kinoshita, N., Yoshida, Y., Tasaki, M., Fujinaka, H., Magdeldin, S., Yaoita, E., Yamamoto, T., 2015c. Label-free quantitative proteomic analysis reveals strong involvement of complement alternative and terminal pathways in human glomerular sclerotic lesions. Journal of proteomics 123, 89-100.
    PMID: 25835966

  • Magdeldin, S., Blaser, R.E., Yamamoto, T., Yates, J.R., 3rd, 2015a. Behavioral and proteomic analysis of stress response in zebrafish (Danio rerio). Journal of proteome research 14, 943-952.
    PMID: 25398274

  • Magdeldin, S., Moresco, J.J., Yamamoto, T., Yates, J.R., 3rd, 2014. Off-Line Multidimensional Liquid Chromatography and Auto Sampling Result in Sample Loss in LC/LC-MS/MS. Journal of proteome research 13, 3826-3836.
    PMID: 25040086

  • Emam, H., Ahmed, E., Abdel-Daim, M., 2018. Antioxidant capacity of omega-3-fatty acids and vitamin E against imidacloprid-induced hepatotoxicity in Japanese quails. Environ Sci Pollut Res Int.
    PMID: 29442305

  • Abdelkhalek, N.K.M., Eissa, I.A.M., Ahmed, E., Kilany, O.E., El-Adl, M., Dawood, M.A.O., Hassan, A.M., Abdel-Daim, M.M., 2017. Protective role of dietary Spirulina platensis against diazinon-induced Oxidative damage in Nile tilapia; Oreochromis niloticus. Environmental toxicology and pharmacology 54, 99-104.
    PMID: 28704756

  • Abo-Elmatty, D.M., Ahmed, E.A., Tawfik, M.K., Helmy, S.A., 2017. Metformin enhancing the antitumor efficacy of carboplatin against Ehrlich solid carcinoma grown in diabetic mice: Effect on IGF-1 and tumoral expression of IGF-1 receptors. International immunopharmacology 44, 72-86.
    PMID: 28088698

  • Ahmed, E.A., Elsayed, D.H., Kilany, O.E., El-Beltagy, M.A., 2017. Multivitamins preventive therapy against subclinical endometritis in buffaloes: Its correlation to NEFA and oxidative stress. Reprod Biol 17, 239-245.
    PMID: 28552375

  • Ahmed, E., Nagaoka, K., Fayez, M., Abdel-Daim, M.M., Samir, H., Watanabe, G., 2015a. Suppressive effects of long-term exposure to P-nitrophenol on gonadal development, hormonal profile with disruption of tissue integrity, and activation of caspase-3 in male Japanese quail (Coturnix japonica). Environ Sci Pollut Res Int 22, 10930-10942.
    PMID: 25772865

  • Ahmed, E., Nagaoka, K., Fayez, M., Samir, H., Watanabe, G., 2015b. Long-term p-nitrophenol exposure can disturb liver metabolic cytochrome P450 genes together with aryl hydrocarbon receptor in Japanese quail. The Japanese journal of veterinary research 63, 115-127.
    PMID: 26563031

  • Samir, H., Sasaki, K., Ahmed, E., Karen, A., Nagaoka, K., El Sayed, M., Taya, K., Watanabe, G., 2015. Effect of a single injection of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) on testicular blood flow measured by color doppler ultrasonography in male Shiba goats. J Vet Med Sci 77, 549-556.
    PMID: 25715956