Shahenda El-Naggar, PhD



  • PhD, Biochemistry and Molecular Biology, School of Medicine, University of Louisville, USA
  • MSc, Bioinformatics, Krieger School of Arts and Science, Johns Hopkins University, USA
  • BSc, Biochemistry, Ain Shams University, Egypt

Research interest:

The main research interest of Dr. El-Naggar is in the field of tumor biology, specifically examining the role of aggresomes and misfolded proteins in pediatric brain tumors and the interplay between unfolded protein response and autophagy.


  • Ruth L. Kirschstein National Research Service Award, USA (NRSA) 2007
  • Misr El-Kheir First Annual Scientific Publications Award for 2010
  • The State Incentive Award in Biological Sciences for 2010
  • L’Oreal- UNESCO for Women in Science Fellowship Award 2011

Selected publications:

  • Fouad, Y. and El-Naggar, S., 2020. (bioaRxiv) Monitoring Autophagy: Not All LC3s Are Created Equal.
  • Mosaab, A., El-Ayadi, M., Khorshed, E.N. et al. Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas. Sci Rep 10, 8368 (2020).
  • Yehia M, Taha H, Salama A, Amer N, Mosaab A, Hassanain O, Refaat A, Yassin D, El-Hemaly A, Ahmed S, El-Beltagy M, Shaalan O, El-Naggar S. Association of Aggresomes with Survival Outcomes in Pediatric Medulloblastoma. Sci Rep. 2019 Aug 30;9(1):12605. doi: 10.1038/s41598-019-49027-x. PubMed PMID: 31471537.
  • Kassab SE, Mowafy S, Alserw AM, Seliem JA, El-Naggar SM, Omar NN, Awad MM. Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1062-1077. Doi: 10.1080/14756366.2019.1613987. PubMed PMID: 31072216; PubMed Central PMCID: PMC6522981.
  • Nassar M, Samaha H, Ghabriel M, Yehia M, Taha H, Salem S, Shaaban K, Omar M, Ahmed N, El-Naggar S. LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma. Sci Rep. 2017 Aug 14;7(1):8022. doi: 10.1038/s41598-017-07403-5. PubMed PMID: 28808307; PubMed Central PMCID: PMC5556083.
  • Gad AZ, El-Naggar S, Ahmed N. Realism and pragmatism in developing an effective chimeric antigen receptor T-cell product for solid cancers. Cytotherapy. 2016 Nov;18(11):1382-1392. doi: 10.1016/j.jcyt.2016.07.004. Epub 2016 Sep 2. Review. PubMed PMID: 27601331.
  • Samaha H, El Naggar S, Ahmed N. Armed hunter killers: discerning the role of adoptive T-cell transfer for glioblastoma. Immunotherapy. 2015;7(5):481-5. doi: 10.2217/imt.15.22. PubMed PMID: 26065474.
  • Taha H, Yehia M, Mahmoud M, El-Beltagy M, Ghabriel M, El-Naggar S. Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. Clin Transl Med. 2015 Mar 3;4:10. doi: 10.1186/s40169-015-0052-7. eCollection 2015. PubMed PMID: 25883769; PubMed Central PMCID: PMC4392037.