• 19057

Shahenda El-Naggar, PhD

 

Education:

  • PhD, Biochemistry and Molecular Biology, School of Medicine, University of Louisville, USA
  • MSc, Bioinformatics, Krieger School of Arts and Science, Johns Hopkins University, USA
  • BSc, Biochemistry, Ain Shams University, Egypt

Research interest:

The main research interest of Dr. El-Naggar is in the field of tumor biology, specifically examining the role of aggresomes and misfolded proteins in pediatric brain tumors and the interplay between unfolded protein response and autophagy.

Awards:

  • Ruth L. Kirschstein National Research Service Award, USA (NRSA) 2007
  • Misr El-Kheir First Annual Scientific Publications Award for 2010
  • The State Incentive Award in Biological Sciences for 2010
  • L’Oreal- UNESCO for Women in Science Fellowship Award 2011

Selected publications:

  • Fouad, Y. and El-Naggar, S., 2020. (bioaRxiv) Monitoring Autophagy: Not All LC3s Are Created Equal.
  • Mosaab, A., El-Ayadi, M., Khorshed, E.N. et al. Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas. Sci Rep 10, 8368 (2020). https://doi.org/10.1038/s41598-020-65272-x
  • Yehia M, Taha H, Salama A, Amer N, Mosaab A, Hassanain O, Refaat A, Yassin D, El-Hemaly A, Ahmed S, El-Beltagy M, Shaalan O, El-Naggar S. Association of Aggresomes with Survival Outcomes in Pediatric Medulloblastoma. Sci Rep. 2019 Aug 30;9(1):12605. doi: 10.1038/s41598-019-49027-x. PubMed PMID: 31471537.
  • Kassab SE, Mowafy S, Alserw AM, Seliem JA, El-Naggar SM, Omar NN, Awad MM. Structure-based design generated novel hydroxamic acid based preferential HDAC6 lead inhibitor with on-target cytotoxic activity against primary choroid plexus carcinoma. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1062-1077. Doi: 10.1080/14756366.2019.1613987. PubMed PMID: 31072216; PubMed Central PMCID: PMC6522981.
  • Nassar M, Samaha H, Ghabriel M, Yehia M, Taha H, Salem S, Shaaban K, Omar M, Ahmed N, El-Naggar S. LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma. Sci Rep. 2017 Aug 14;7(1):8022. doi: 10.1038/s41598-017-07403-5. PubMed PMID: 28808307; PubMed Central PMCID: PMC5556083.
  • Gad AZ, El-Naggar S, Ahmed N. Realism and pragmatism in developing an effective chimeric antigen receptor T-cell product for solid cancers. Cytotherapy. 2016 Nov;18(11):1382-1392. doi: 10.1016/j.jcyt.2016.07.004. Epub 2016 Sep 2. Review. PubMed PMID: 27601331.
  • Samaha H, El Naggar S, Ahmed N. Armed hunter killers: discerning the role of adoptive T-cell transfer for glioblastoma. Immunotherapy. 2015;7(5):481-5. doi: 10.2217/imt.15.22. PubMed PMID: 26065474.
  • Taha H, Yehia M, Mahmoud M, El-Beltagy M, Ghabriel M, El-Naggar S. Incidence of kiaa1549-braf fusion gene in Egyptian pediatric low grade glioma. Clin Transl Med. 2015 Mar 3;4:10. doi: 10.1186/s40169-015-0052-7. eCollection 2015. PubMed PMID: 25883769; PubMed Central PMCID: PMC4392037.