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Bone Marrow Transplant Unit

What do we need to know about BMT

  • A bone marrow transplant is a procedure that infuses healthy blood-forming stem cells into your body to replace your damaged or diseased bone marrow.

  • The spongy tissue inside bone (bone marrow) contains stem cells.
    • Stem cells are ‘mother’ cells which change and evolve to become other blood cells.
    • A stem cell divides into more cells and throughout this process its ‘daughter cells’ will be differentiated into various blood cells e.g. red blood cells, white blood cells and platelets.

  • You might need a bone marrow transplant if your bone marrow stops working and does not produce enough healthy blood cells.

  • Bone marrow transplants may use cells from your own body (autologous transplant) or from a healthy related or unrelated donor (allogeneic transplant).



A bone marrow transplant may be used to:

  • Safely allow treatment of your condition with high doses of chemotherapy or radiation by replacing or rescuing the bone marrow damaged by treatment.
  • Replace diseased or damaged marrow with new stem cells.
  • Provide new stem cells, which can help kill cancer cells directly.
  • Autologous transplant

  • Allogeneic transplant
  • Autologous SCT indications
    • Relapsed Non-Hodgkin Disease
    • Relapsed/refractory Hodgkin Disease
    • High risk neuroblastoma
    • High risk and infantile Medulloblastoma
    • Extra ocular Retinoblastoma
    • Relapsed Wilms Tumor, Ewing Sarcoma & Germ cell tumor

  • Allogeneic HSCT indications
MalignantBenign disorders

Leukemia

  1. Acute myeloid leukemia
  2. Acute lymphoblastic leukemia
  3. Chronic myeloid leukemia
  4. Juvenile Myelomonocytic Leukemia

Lymphoma

  1. Relapsed Non-Hodgkin Disease
  2. Relapsed Hodgkin Disease

  • Hemoglobinopathies
  • Immune deficiencies
  • Congenital Bone marrow failure
  • Inborn errors of metabolism
  • Aplastic anemia
  • Osteopetrosis
  • For many people who have leukemia, lymphoma, or certain other blood disorders, BMT offers the best chance of a cure.
  • But only about 25% of people who need an allogeneic transplant — the type of transplant in which donor cells are used — have a sibling who is a suitable genetic match.
  • The remaining 75% usually look to registries of unrelated volunteers to find a compatible donor.