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Dr. El-Naggar Lab

Research Focus

The main research interest of Dr. El-Naggar is in the field of tumor biology, specifically examining the role of misfolded proteins in pediatric brain tumors, and the interaction between autophagy and the cellular protein quality control, with particular interest in the role of aggresomes in cancer pathogenesis.

Research Themes

  1. Mechanism of aggresome formation in pediatric brain tumors primarily in choroid plexus tumors and medulloblastoma.

  2. Identify the role of autophagy in aggresome clearance and the feedback loop between autophagy and UPR.

  3. Characterize the inheritance pattern of aggresomes in cancer cells.